Why do barbiturates lead to hypertrophy of smooth ER and why do we need to increase the dose?
Barbiturates are CYP450 oxidase inducers. This enzyme is produced by smooth ER.. So there will be hypertrophy.
Ok agreed. But how the person becomes tolerant to the drug?
It is because the hypertrophied smooth ER metabolises the drug more causing adaptation.
No comments:
Post a Comment
This is express yourself space. Where you type create something beautiful! <3
Wondering what do I write? Well...
Tell us something you know better. You are a brilliant mind. Yes, you are! ^__^
Ask about something you don't understand @_@?
Compliment... Say something nice! =D
Be a good critic and correct us if something went wrong :|
Go ahead. Comment all you like here! (:
PS: We have moderated comments to reduce spam. ALL comments that are not spam will be published on the website.